AKONGO JOANITA2024-10-152024-10-152024-09-02https://hdl.handle.net/20.500.12311/1852ABSTRACT This research report was undertaken to examine effects of youth substance abuse on mental disorders in Namatala slums, Mbale city; to find out the effect of tobacco use on substance dependence in Namatala slums, to determine the effect of alcohol use on prevalence of anxiety disorders in Namatala slums, to assess the effect of inhalant use on social isolation in Namatala slums. The researcher used a sample size of 63 respondents and used questionnaires to collect data and later the data was analyzed using the statistical package for social sciences (SPSS). Results of the first objective showed that tobacco use has a significant effect on substance dependence in Namatala slums. Supported by the following responses; 30% strongly agreed, 24% Agreed to the statement that tobacco use can increase the likelihood of developing dependence on other substances due to shared pathways in the brain’s reward system; 33% strongly agreed, 29% agreed to the statement that chronic tobacco use alters brain chemistry. Results of the second objective revealed that alcohol use has a significant effect on prevalence of anxiety disorders in Namatala slums. Supported by the following responses; 35% strongly agreed, 21% Agreed to the statement that alcohol can directly cause anxiety, particularly during withdrawal, leading to the development of anxiety disorders, 33% strongly agreed, 47% Agreed to the statement that individuals may use alcohol to self-medicate anxiety, which can worsen symptoms and lead to a cycle of dependence and increased anxiety. Results of the third objective showed that inhalant use has a significant effect on social isolation in Namatala slums. 54% strongly agreed, 21% Agreed to the statement that inhalant use can cause cognitive impairments, making it difficult for users to engage in social interactions, leading to isolation, 43% strongly agreed ,25% agreed to the statement that prolonged inhalant use can erode social skills. There is need for people to break the cycle of addiction and lower the risk of transitioning to other drugs. Interventions such as public health campaigns, stricter regulations on tobacco advertising and sales, and increased taxes on tobacco products can reduce its accessibility and appeal, especially among young people.enThesis